Your Questions Answered

How can hemp extract help menstrual cramps and PMS symptoms in general? 


Many plant-based and natural products have been researched for their potential in relieving pain caused by menstrual cramps. Menthol, Trolamine and hemp extract have all been found to have analgesic and anti-inflammatory properties. Hemp extract is also rich in certain other compounds that have shown to have discomfort relieving elements. Menthol has shown in studies to relieve dysmenorrhea. Our topical creams provide targeted and effective relief. 


Hemp extract has shown to soothe and manage the emotional symptoms associated with PMS. Studies also suggest it has sleep regulating and mood-stabilizing effects. Consistently shown is the reduction of symptoms associated with anxiety. Evidence shows hemp extract can have a calming effect on the central nervous system, keeping the mind and body balanced and providing both physical and emotional relief. Hemp is safe for everyday use and benefits your overall wellness during your cycle.


Is it safe to use the Holief creams near my intimate region?  

Our creams are formulated to be safe wherever you need to use them. If you experience any adverse reaction such as irritation or burning when applying any of our creams, please stop application and consult your physician. 


Will hemp extract affect oral contraceptive methods? 

Hemp extract, like oral contraceptive methods, is processed by enzymes in the liver before entering the body’s bloodstream. In this sense, there is a possibility that hemp extract might compete or interfere with the contraceptive’s metabolization. This could lead to an increased risk of side effects or for the medication to not be as effective. To be safe, we recommend consulting with your doctor or pharmacist if your current contraceptive method may be affected by hemp extract.  


Are hemp-extract edibles considered approved drugs? 

No. Hemp-extract edibles are dietary supplements and, as such, these products are not intended to diagnose, treat, cure, or prevent any disease.  

How can hemp extract help me sleep better?  

Hemp extract has been shown to have anxiolytic effects, meaning that it can present a calming effect on the nervous system. Additional studies have also shown that hemp extract may have sleep promoting effects, increasing REM sleep, onset, and total sleep. 

How can melatonin and 5-HTP help me sleep better? 

5-hydroxytryptophan (5-HTP) is an amino acid produced within the body that is involved in the natural obtention of 5-hydroxytryptamine (serotonin) and melatonin, both hormones that are involved in regulating the sleep-wake cycle in humans. Studies have shown that 5-HTP intake can increase REM sleep, which helps to improve overall sleep quality. 

Melatonin is a hormone produced within the body, and only released at night. Melatonin has been shown to synchronize the circadian rhythm, which heavily influences the initiation, duration, and quality of sleep. Exogenous supplementation of melatonin has shown significant clinical effect in disorders associated with decreased or misaligned melatonin rhythms, for example, circadian rhythm-related sleep disorders, jet lag, and late shift work. 

Supplementation with both molecules while getting ready for bed can help signal your brain that it is time to sleep and that the body should start winding down. However, for it to be effective, it is important to establish a bedtime routine where electronics are used less and substances such as caffeine and alcohol are avoided.       

Will hemp extract make me feel tired?  

It has been reported that some secondary effects of hemp extract can be drowsiness or lightheadedness. However, very high doses are required. 

Can kids take these products to help them sleep? 

Since hemp extract is relatively new, it hasn’t been extensively tested for use with children, and no longitudinal studies on its effects have been done.  

Regarding melatonin, the U.S. Food and Drug Administration has not approved melatonin for use with children and adolescents. Melatonin is considered relatively safe for short-term use and has few risks. However, some children who take melatonin supplements may experience mild symptoms, such as bedwetting, drowsiness, headaches, and agitation.  

We recommend consulting with a pediatrician if Holief products are right for your kids. 

Can products with melatonin help me with jetlag? 

Jetlag is a sleep disorder where your circadian rhythms are not aligned with the day/night cycle because of travel. Our products contain melatonin, which can help synchronize the circadian rhythm such that it aligns to the time of your new location. 

Can I consume hemp extract products if I take prescription drugs? 

Hemp extract, like many medications and other substances we consume, is processed or broken down by enzymes in the liver before entering your bloodstream. Therefore, if you are taking another medication with hemp extract, both substances may compete for these enzymes, or hemp extract may interfere with the metabolization of the medication. This may affect the concentration of the medication and can lead to the medication not working, or an increased risk of side effects. To stay safe, we recommend consulting with your doctor or pharmacist if you are taking medications or have underlying medical conditions and are considering consuming products containing hemp products.  

How can menthol help with muscular and joint pain? 

Menthol acts as a topical analgesic by interacting with the network of nerves present within the skin and by activating central analgesic pathways. This ingredient additionally stimulates cold receptors in our skin, generating a perception of cold, which is why it provides a refreshing sensation when applied. Menthol is also a vasodilator and may act as vasorelaxant, which means that it decreases arterial blood flow. All these effects combine to provide relief from discomfort related to muscular and joint pain.  

Will the Holief Ease gummies or the Holi-Balance Oral drops make me feel high?  

All our products are THC-free, the substance responsible for causing psychoactive effects. Therefore, none of our hemp extract edibles will produce a “high” feeling, which makes them perfectly safe to consume at any time. 

Will hemp extract isolate products trigger a positive doping test? 

Hemp extract isolate is currently not listed on the World Anti-Doping Agency’s prohibited list. This means that it is permitted to use in-competition and its presence in a urine sample will not be considered as an Adverse Analytical Finding (positive doping test). Nevertheless, if you are an athlete about to enter a competition, we highly suggest reviewing if Holief products are approved for in-competition usage according to their rules and regulations. 

Will Holief’s hemp extract products trigger a positive drug test?  

A drug abuse screening test (DAST) will be positive if the amount of T-metabolite is more than 50 ng/ml. Holief products are THC-free, and therefore will not produce the metabolite whose detection can cause a positive DAST when consumed. In conclusion, consuming Holief’s products that contain hemp extract do not put you at risk of getting a positive drug test. 

How do these products help me with anxiety or stress?  

Hemp extract has shown to have a broad pharmacological profile, including interactions with several receptors in the body that are known to regulate behaviors related to fear and anxiety. The natural calming effect produced by hemp extract and other oils in our formulation stabilizes your mood and promotes relaxation.   

What is hemp extract isolate?  

Hemp extract isolate is one of the multiple beneficial cannabinoids that is present in the hemp plant.  It boosts the immune and central nervous system diminishing infections, anxiety, and mood swings. It regulates hormones that help improve bone density, eases hot flashes, and balances hormones during menopause. Its usage has also shown a significant reduction in cases of breast cancer and autoimmune conditions.   

In addition to the above health benefits, hemp extracted oil is also ideal for skin health. It is one of the best products for smooth hair and to soothe dry & sensitive skin. It also has analgesic and pain-relieving properties.  Hemp extract has shown to soothe aching joints and pain. 

Can I become addicted to consuming hemp extract from Holief products? 

Addiction is generally defined as the use of a substance in a compulsive manner that often continues despite it presenting harmful consequences. Substances that lead to addiction tend to affect the pleasure center of the brain, such that the person develops the need to consume it. Because they interact with the brain in such way, this means that they are psychoactive substances.  

All our products are THC-free, which means that the hemp extract used in Holief does not cause any psychoactive effects. Moreover, studies have shown that hemp extract isolate does not present any indication of having abuse or dependence potential. 

In conclusion, there is very little risk of becoming addicted to the THC-free hemp extract contained in Holief products.  

What is the maximum daily hemp extract dose recommended?
Does hemp extract produce any secondary effects? 

According to Harvard Health, hemp extract may cause drowsiness, lightheadedness, nausea, diarrhea or dry mouth. However, these secondary effects can appear after very high doses of hemp extract. Studies in humans have shown that oral intake of up to 160 mg of hemp extract did not produce any undesired or adverse secondary effects. Other studies have shown that in doses of up to 600 mg, hemp extract does not interfere with many psychomotor and physiological functions in the body, such as heart rate, blood pressure, or performance in learning tests. In contrast, our edibles contain maximum 50 mg of hemp extract per gummy.  

Are there any long-term effects of consuming hemp-extract daily?  

Up until this moment, studies have shown that consuming hemp extract daily is safe as it does not seem to produce any toxicity or serious side effects. For example, one study has shown that the daily oral administration of 300 mg of hemp extract for up to 135 days was well tolerated by participants of the study, and no serious adverse effects were detected on neurological or physical examinations.  

Are Holief products tested on animals? 

No. All our products are cruelty-free, meaning that none of them are tested on animals. 

Can I consume Holief edibles if I am pregnant? 

Up until now, there are not many studies related to the safety of consuming hemp extract during pregnancy. In this sense, and to stay safe, we recommend consulting with your physician before consuming Holief products if you are pregnant.  

Is hemp extract legal? Do I need a prescription to use hemp extract products?  

With the passing of the 2018 Farm Bill, the cultivation of hemp plants became federally legal. Hemp extract does not produce a high and is, considered to be, safe and well-tolerated. Because of this, you do not need a prescription to access hemp extract products. 

What is the entourage effect? 

Hemp extract contains multiple compounds including Phytocannabinoids, terpenes, flavonoids, etc. These different substances act together synergistically to produce the beneficial effects observed when you use products with hemp extract. This synergistic action is called the Entourage Effect.   

Are Holief products made with all-natural ingredients?  

Most of the ingredients used in our products are of natural origin. Some of them, melatonin or Vitamin E are produced synthetically, always keeping the highest production standards to ensure your safety. Our products are paraben-free, silicon-free and do not derive from petrochemicals.